TERT-BUTYL 3-BROMO-1H-INDOLE-1-CARBOXYLATE
3-Bromoindole-1-Carboxylic acid Tert-Butyl ester
CAS: 143259-56-7
Molecular Formula: C13H14BrNO2
TERT-BUTYL 3-BROMO-1H-INDOLE-1-CARBOXYLATE - Names and Identifiers
TERT-BUTYL 3-BROMO-1H-INDOLE-1-CARBOXYLATE - Physico-chemical Properties
| Molecular Formula | C13H14BrNO2 |
| Molar Mass | 296.16 |
| Density | 1.37±0.1 g/cm3(Predicted) |
| Boling Point | 367.9±34.0 °C(Predicted) |
| Flash Point | 176.3°C |
| Vapor Presure | 1.33E-05mmHg at 25°C |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Refractive Index | 1.576 |
TERT-BUTYL 3-BROMO-1H-INDOLE-1-CARBOXYLATE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Hazard Note | Irritant |
TERT-BUTYL 3-BROMO-1H-INDOLE-1-CARBOXYLATE - Introduction
1-N-BOC-3-bromoindole is an organic compound with the chemical structure C11H12BrNO2.
Nature:
1-N-BOC-3-bromoindole is a white crystalline solid with high melting and boiling points. It is a protecting group of bromoindole, and the amino group in the indole molecule is protected by adding BOC(n-tert-butoxycarbonyl) at the 1 position.
Use:
1-N-BOC-3-bromoindole is an important intermediate in organic synthesis, which is commonly used in the synthesis of similar compounds. It can act as a precursor for drugs and pesticides, and can also be used to synthesize biologically active molecules.
Preparation Method:
1-N-BOC-3-bromoindole can be prepared by the following steps:
1. In the presence of hydrogen bromide, indole is condensed with n-tert-butyl alcohol to produce 1-N-BOC-3-tert-butoxycarbonylchloroindole;
2. the prepared chloroindole reacts with triethylamine to produce the final 1-N-BOC-3-bromoindole product.
Safety Information:
1-N-BOC-3-bromoindole is relatively stable under general conditions, but contact with oxidants and strong acids should be avoided. Appropriate protective measures should be taken during handling, including wearing chemical protective gloves and goggles. In addition, it should be stored in a dry, cool place, away from direct sunlight. Detailed safety information should be evaluated and understood in terms of dose and specific experimental conditions. In the use of the process, the need to strictly abide by the laboratory safety procedures.
Nature:
1-N-BOC-3-bromoindole is a white crystalline solid with high melting and boiling points. It is a protecting group of bromoindole, and the amino group in the indole molecule is protected by adding BOC(n-tert-butoxycarbonyl) at the 1 position.
Use:
1-N-BOC-3-bromoindole is an important intermediate in organic synthesis, which is commonly used in the synthesis of similar compounds. It can act as a precursor for drugs and pesticides, and can also be used to synthesize biologically active molecules.
Preparation Method:
1-N-BOC-3-bromoindole can be prepared by the following steps:
1. In the presence of hydrogen bromide, indole is condensed with n-tert-butyl alcohol to produce 1-N-BOC-3-tert-butoxycarbonylchloroindole;
2. the prepared chloroindole reacts with triethylamine to produce the final 1-N-BOC-3-bromoindole product.
Safety Information:
1-N-BOC-3-bromoindole is relatively stable under general conditions, but contact with oxidants and strong acids should be avoided. Appropriate protective measures should be taken during handling, including wearing chemical protective gloves and goggles. In addition, it should be stored in a dry, cool place, away from direct sunlight. Detailed safety information should be evaluated and understood in terms of dose and specific experimental conditions. In the use of the process, the need to strictly abide by the laboratory safety procedures.
Last Update：2024-04-09 20:52:54
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View History
TERT-BUTYL 3-BROMO-1H-INDOLE-1-CARBOXYLATE
N-[(9H-芴-9-基甲氧基)羰基]-3-(2-呋喃基)-D-丙氨酸
dimethyl [[3-[(2-methyl-1-oxoallyl)amino]phenyl]sulphonyl]phosphoramidate
(Z)-hexadec-7-en-1-ol
2',3'-dideoxyadenosine
2-(3-(二甲氨基)苯基)乙酸
2H-2,6-Methanofuro[2,3-c]pyridine(9CI)
(7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid 2-oxo-2-phenylethyl ester
四(五氟苯基)硼酸三苯基甲酯
乙酰-酪氨酸乙酯
N-[(9H-芴-9-基甲氧基)羰基]-3-(2-呋喃基)-D-丙氨酸
dimethyl [[3-[(2-methyl-1-oxoallyl)amino]phenyl]sulphonyl]phosphoramidate
(Z)-hexadec-7-en-1-ol
2',3'-dideoxyadenosine
2-(3-(二甲氨基)苯基)乙酸
2H-2,6-Methanofuro[2,3-c]pyridine(9CI)
(7,7-Dimethyl-2-oxobicyclo[2.2.1]heptan-1-yl)methanesulfonic acid 2-oxo-2-phenylethyl ester
四(五氟苯基)硼酸三苯基甲酯
乙酰-酪氨酸乙酯